Most definitely. But on one condition...
In this game you need to truly feel like your playing as an ODST/non-supersoldier. Even with the various few changes they made in the first ODST it just felt like more of a re-skin. I don't mind if you have a 'stamina' system for your health like in the past game but there should be lots of key differences in gameplay mechanics between Spartans and ODSTs. Going back to health, Spartans 'life points' will completely recharge after a few seconds just like they do in 2, 3, 4, and 5 but ODSTs health points will not recharge. Meaning you'll likely have to seek out health packs, basically being like CE, ODST, and Reach. Spartans should have infinite sprint while an ODST has limited sprint at best (like Halo 4) and no sprint at worst. Spartan can carry practically everything, while an ODST is mostly limited to just Human weapons as some Covenant and Forerunner weapons would be too heavy or unwieldy for them. They also shouldn't be able to unmount and walk with a turret. Out of the weapons ODSTs can use there should be noticeably more recoil as oppose to Spartans who have practically no recoil with any of the weapons. For example, in the Halo games you don't so much as flinch when firing a sniper shot but as an ODST you should experience recoil and be encouraged to either crouch or lay prone to efficiently use the weapon and most weapons for that matter! Reloading your weapons as an ODST should noticeably feel a little slower as well. As an ODST you need a drop pod but Spartans don't even need that and can just drop using their thrusters and tough armor! You wouldn't be able to board enemy controlled vehicles and of course, ODSTs couldn't ground-pound or Spartan-charge either!
The list could go on but those I believe are all the major points that would really make you feel you were playing a true ODST game!
Sure, it should have a unique story but if the gameplay isn't unique or that amazing then it kinda makes the story not worth going through. After all, this is a video game.